Sjögren Lymphoma Risk — NDEB AFK MCQ

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HardOral MedicineSjögren Lymphoma RiskNDEB AFK

A patient presents with xerostomia, bilateral parotid enlargement, and positive anti-SSB (La) antibodies. Which associated systemic condition is this patient at increased risk for developing?

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Correct answer: B — Non-Hodgkin B-cell lymphoma (MALT lymphoma)

Patients with Sjögren syndrome have a 16-44 times increased risk of developing non-Hodgkin B-cell lymphoma, particularly mucosa-associated lymphoid tissue (MALT) lymphoma of the salivary glands. Risk factors for lymphomatous transformation include persistent parotid enlargement, splenomegaly, lymphadenopathy, palpable purpura, low C4, cryoglobulinaemia, and CD4+ T-cell lymphopenia. Long-term monitoring of salivary gland swelling is essential.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016