Opioid Reversal — NDEB AFK MCQ
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Correct answer: C — Naloxone
Naloxone (Narcan) is a competitive opioid receptor antagonist that rapidly reverses opioid-induced respiratory depression, sedation, and hypotension. It is administered 0.1-0.4 mg IV (onset 1-2 minutes) or 0.4-0.8 mg IM/SC (onset 2-5 minutes) and repeated every 2-3 minutes as needed. Because its half-life (30-90 min) is shorter than most opioids, re-sedation can occur and repeat dosing or continuous infusion may be needed. Flumazenil reverses benzodiazepines, not opioids.
Reference: Malamed – Sedation: A Guide to Patient Management, 6th ed., 2018