N₂O Contraindications — NDEB AFK MCQ
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Correct answer: A — COPD or severe respiratory disease
Nitrous oxide is contraindicated in patients with COPD (chronic obstructive pulmonary disease) or severe respiratory compromise because: (1) N₂O reduces the hypoxic drive that may be the primary respiratory stimulus in some COPD patients; (2) it may worsen respiratory depression; (3) high-flow oxygen (needed during N₂O sedation and recovery) may suppress respiratory drive in CO₂-retaining COPD patients. Other contraindications include bowel obstruction, pneumothorax, middle ear surgery, first trimester pregnancy, and severe emotional/psychiatric disturbance.
Reference: Malamed – Sedation: A Guide to Patient Management, 6th ed., 2018