NSAID Cardiovascular Risk — NDEB AFK MCQ
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Correct answer: A — Naproxen
Naproxen has been consistently shown to carry the lowest cardiovascular risk among commonly used NSAIDs. Meta-analyses (CNT Collaboration, Lancet 2013) demonstrated that naproxen has a neutral cardiovascular risk profile, while diclofenac and COX-2 selective inhibitors (celecoxib, etoricoxib) carry increased risk of thrombotic cardiovascular events. Rofecoxib (Vioxx) was withdrawn from the market in 2004 due to increased MI risk. For dental pain in patients with cardiovascular risk factors, naproxen or ibuprofen (short-term) are preferred.
Reference: Katzung – Basic and Clinical Pharmacology, 15th ed., 2021