Drug-Induced Xerostomia — NDEB AFK MCQ
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Correct answer: C — Amitriptyline (tricyclic antidepressant)
Tricyclic antidepressants (TCAs) such as amitriptyline have potent anticholinergic (antimuscarinic) effects that inhibit parasympathetic stimulation of salivary glands, causing significant xerostomia. Other drug classes commonly causing xerostomia include antihistamines, antihypertensives, diuretics, opioids, benzodiazepines, and antipsychotics. Xerostomia increases caries risk, candidal infection risk, and reduces denture retention. Over 400 medications list dry mouth as a side effect.
Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016