Ameloblastic Fibroma — NDEB AFK MCQ

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HardOral PathologyAmeloblastic FibromaNDEB AFK

A panoramic radiograph of a 9-year-old reveals a large, well-defined multilocular radiolucency in the posterior mandible displacing developing tooth buds. Biopsy shows stellate reticulum-like cells and peripheral palisading. What is the most likely diagnosis?

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Correct answer: E — Ameloblastic fibroma

In a 9-year-old, a multilocular radiolucency with mixed epithelial and ectomesenchymal components on biopsy (epithelium resembling ameloblastic epithelium within a primitive ectomesenchymal stroma resembling dental papilla) is characteristic of ameloblastic fibroma. It is a true mixed odontogenic tumour occurring predominantly in children and young adults (mean age ~15 years). Unlike ameloblastoma, which is primarily epithelial and rare in children, ameloblastic fibroma has a neoplastic mesenchymal component.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016