Type I Hypersensitivity — NDEB AFK MCQ

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EasyBiomedical SciencesType I HypersensitivityNDEB AFK

Which immunoglobulin class is primarily responsible for type I (immediate) hypersensitivity reactions such as latex allergy?

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Correct answer: E — IgE

IgE is the immunoglobulin responsible for type I (immediate/anaphylactic) hypersensitivity reactions. IgE binds to high-affinity FcεRI receptors on mast cells and basophils. Upon re-exposure to the allergen, cross-linking of surface-bound IgE triggers degranulation, releasing histamine, leukotrienes, and prostaglandins. This underlies anaphylaxis, allergic asthma, and latex allergy — all relevant dental emergencies.

Reference: Abbas – Cellular and Molecular Immunology, 10th ed., 2021