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Amelogenin Genetics — NDEB AFK MCQ

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HardBiomedical SciencesAmelogenin GeneticsNDEB AFK

Amelogenin, the predominant protein of the developing enamel matrix, is encoded by a gene located on which chromosome?

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Correct answer: B — X chromosome (and Y chromosome)

Amelogenin is encoded by the AMELX gene on the X chromosome (and a smaller copy, AMELY, on the Y chromosome). Mutations in AMELX cause X-linked amelogenesis imperfecta. Amelogenin comprises approximately 90% of the enamel matrix protein during development and is progressively removed during enamel maturation, leaving a highly mineralised (96% inorganic) mature enamel.

Reference: Nanci – Ten Cate's Oral Histology, 9th ed., 2017