Gardner Syndrome — NDEB AFK MCQ

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HardOral PathologyGardner SyndromeNDEB AFK

Which of the following conditions is an autosomal dominant disorder characterised by multiple supernumerary teeth, osteomas of the jaw, and intestinal polyps with malignant potential?

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Correct answer: B — Gardner syndrome

Gardner syndrome is an autosomal dominant condition (variant of familial adenomatous polyposis, FAP) caused by APC gene mutation. It is characterised by multiple intestinal polyps with high malignant potential (virtually 100% progression to colorectal carcinoma), osteomas (especially jaw and skull), supernumerary teeth, odontomas, and soft tissue tumours (epidermoid cysts, fibromas, desmoid tumours). Early identification of oral signs by dentists can be life-saving.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016