Enamel Matrix Derivative — NDEB AFK MCQ

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HardPeriodontologyEnamel Matrix DerivativeNDEB AFK

Which growth factor is commonly used in periodontal regenerative procedures and is the active component of Emdogain?

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Correct answer: A — Enamel matrix derivative (EMD/amelogenin)

Emdogain contains enamel matrix derivative (EMD), primarily amelogenin proteins, extracted from porcine developing tooth buds. When applied to a periodontal defect, EMD mimics the processes of tooth development and promotes regeneration of cementum, periodontal ligament, and alveolar bone. EMD is indicated for intrabony defects and recession defects. PDGF (recombinant) is the active component of GEM 21S used in regeneration.

Reference: Newman – Newman and Carranza's Clinical Periodontology, 13th ed., 2019