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Sjögren Syndrome Diagnosis — NDEB AFK MCQ

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HardOral MedicineSjögren Syndrome DiagnosisNDEB AFK

Which investigation is most appropriate for evaluating suspected Sjögren syndrome in a patient with xerostomia and xerophthalmia?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Labial minor salivary gland biopsy

Labial minor salivary gland biopsy is the most specific diagnostic test for Sjögren syndrome. Histological findings of focal lymphocytic sialadenitis with a focus score ≥1 (≥50 lymphocytes per 4 mm²) are a major criterion for diagnosis. Serological markers (anti-SSA/Ro, anti-SSB/La), Schirmer test (for xerophthalmia), and salivary flow rate measurement complement the diagnosis. The ACR/EULAR 2016 classification criteria are used.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016