Leukoedema — NDEB AFK MCQ

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ModerateOral PathologyLeukoedemaNDEB AFK

A 55-year-old patient presents with a white, corrugated, bilateral lesion on the buccal mucosa that cannot be rubbed off. Biopsy shows epithelial hyperkeratosis with chevron-pattern parakeratin. What is the most likely diagnosis?

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Correct answer: C — Leukoedema

Leukoedema is a benign mucosal variation appearing as a diffuse, bilateral, whitish-grey, corrugated lesion of the buccal mucosa. It characteristically disappears when the mucosa is stretched. Histologically, it shows intracellular oedema of the spinous layer with a chevron-pattern surface parakeratin. It is more common in individuals with darker skin pigmentation and requires no treatment.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016