Enflurane Epileptiform EEG — FRCA Primary MCQ

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HardPharmacology - Inhalational AgentsEnflurane Epileptiform EEGFRCA Primary

The volatile agent enflurane has which unique property compared to other volatile agents?

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Correct answer: C — It can cause epileptiform EEG activity particularly at high concentrations with hypocapnia

Enflurane (rarely used now) can produce epileptiform EEG patterns and frank seizure activity particularly at high concentrations (>2 MAC) with hypocapnia. This is unique among volatile agents. It also produces dose-dependent renal fluoride ions. MAC = 1.68%. Blood:gas coefficient = 1.91.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care