DKA Ketone Bodies — FRCA Primary MCQ
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Correct answer: B — Accumulation of ketone bodies (beta-hydroxybutyrate and acetoacetate) due to uninhibited lipolysis and hepatic ketogenesis
In DKA insulin deficiency and glucagon excess cause: uninhibited lipolysis → free fatty acids → hepatic beta-oxidation → ketone bodies (beta-hydroxybutyrate / acetoacetate / acetone). These strong organic acids consume bicarbonate producing a high anion gap metabolic acidosis. Treatment: IV insulin / fluid resuscitation / potassium replacement / and monitoring.
Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist