Metabolic Alkalosis Hypoventilation — FRCA Primary MCQ

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ModeratePhysiology - RespiratoryMetabolic Alkalosis HypoventilationFRCA Primary

In a metabolic alkalosis which compensatory response occurs?

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Correct answer: D — Hypoventilation to increase PaCO2 (limited by hypoxia drive)

Respiratory compensation for metabolic alkalosis: hypoventilation raises PaCO2 to partially correct pH. However compensation is limited because hypoventilation eventually causes hypoxia which stimulates ventilation. Expected PaCO2 rises approximately 0.7 mmHg for each 1 mmol/L rise in HCO3-. Complete compensation is unusual.

Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist