PGI2 NO Vasodilation Antiplatelet — FRCA Primary MCQ

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ModeratePhysiology - CardiovascularPGI2 NO Vasodilation AntiplateletFRCA Primary

Regarding vascular endothelium which substance is produced that causes vasodilation and inhibits platelet aggregation?

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Correct answer: E — Prostacyclin (PGI2) and nitric oxide

Healthy vascular endothelium produces: prostacyclin (PGI2 — vasodilator / inhibits platelet aggregation) and nitric oxide (vasodilator / inhibits platelet adhesion and aggregation). These counterbalance prothrombotic mediators (thromboxane A2 from platelets / endothelin-1). Endothelial dysfunction (atherosclerosis / diabetes / hypertension) shifts the balance towards vasoconstriction and thrombosis.

Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist