Cyclizine H1 Muscarinic Antiemetic — FRCA Primary MCQ
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Correct answer: B — Histamine H1 (and muscarinic)
Cyclizine is a piperazine derivative with histamine H1 antagonist and muscarinic antagonist properties. It acts on the vomiting centre and vestibular system. It is effective for motion sickness and opioid-induced nausea. Side effects include: drowsiness / dry mouth / and tachycardia (anticholinergic). It should be used with caution in heart failure.
Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care