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Rivaroxaban Factor Xa Inhibitor — FRCA Primary MCQ

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ModeratePharmacology - CardiovascularRivaroxaban Factor Xa InhibitorFRCA Primary

The direct oral anticoagulant rivaroxaban acts by:

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Correct answer: EInhibiting factor Xa directly

Rivaroxaban is a direct oral factor Xa inhibitor. It binds directly to Xa (not requiring AT III as a cofactor unlike heparin). Other direct Xa inhibitors include apixaban and edoxaban. Dabigatran is a direct thrombin (IIa) inhibitor. These DOACs have more predictable pharmacokinetics than warfarin and do not require routine monitoring.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care