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Dopamine Beta-1 Dose Range — FRCA Primary MCQ

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HardPharmacology - CardiovascularDopamine Beta-1 Dose RangeFRCA Primary

A critically ill patient is oliguric but adequately volume resuscitated. A colleague proposes dopamine 1 microgram kg−1 min−1 solely to prevent acute kidney injury. Which response is best supported?

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Correct answer: CAvoid dopamine because renal benefit is unproven and harm possible

The best answer is “Avoid dopamine because renal benefit is unproven and harm possible”. The UK SmPC explicitly advises against routine low-dose dopamine to prevent or treat acute renal failure because clinical renal protection has not been demonstrated and adverse cardiovascular or endocrine effects can further compromise critically ill patients. A transient diuresis is not equivalent to improved renal outcome. Management should address perfusion, obstruction, nephrotoxins and the underlying cause.

Reference: Dopamine hydrochloride concentrate for infusion, UK SmPC: https://www.medicines.org.uk/emc/product/6619/smpc; Royal College of Anaesthetists, Primary FRCA syllabus v2.2: https://www.rcoa.ac.uk/sites/default/files/documents/2026-01/Primary-FRCA-Syllabus.pdf