Mu Receptor Analgesia Resp Depression — FRCA Primary MCQ

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EasyPharmacology - AnalgesicsMu Receptor Analgesia Resp DepressionFRCA Primary

Regarding opioid receptor subtypes which receptor is primarily responsible for supraspinal analgesia respiratory depression and euphoria?

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Correct answer: A — Mu (μ)

The mu receptor (MOP / MOR) mediates: supraspinal analgesia (μ1) / spinal analgesia / respiratory depression (μ2) / euphoria / miosis / physical dependence / reduced GI motility / and pruritus. Two subtypes: μ1 (analgesia) and μ2 (respiratory depression / GI effects). Most clinically used opioids are primarily mu-agonists.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care