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Schnider Model Covariates — FRCA Primary MCQ

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ModeratePharmacology - Intravenous AnaestheticsSchnider Model CovariatesFRCA Primary

Regarding the Schnider pharmacokinetic model for propofol TCI which patient covariates does it use?

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Correct answer: B — Age and weight and height and lean body mass

The Schnider model uses age / total body weight / height / and lean body mass (calculated from height and weight) to individualise the three-compartment PK parameters. It targets effect-site concentration by default. The Marsh model uses only total body weight and targets plasma concentration. The Schnider model is preferred in elderly and obese patients.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care