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ACE Pulmonary Endothelium — FRCA Primary MCQ

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EasyPhysiology - CardiovascularACE Pulmonary EndotheliumFRCA Primary

Angiotensin-converting enzyme (ACE) is located predominantly in which organ?

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Correct answer: E — Lung (pulmonary endothelium)

ACE is a membrane-bound enzyme located predominantly on the pulmonary vascular endothelium. The lung is ideally positioned to process the entire venous return. ACE converts angiotensin I (decapeptide) to angiotensin II (octapeptide) by removing two amino acids. ACE also degrades bradykinin (a vasodilator) which explains the cough side effect of ACE inhibitors.

Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist