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Triple Response of Lewis — FRCA Primary MCQ

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ModeratePhysiology - CardiovascularTriple Response of LewisFRCA Primary

The triple response of Lewis to skin injury consists of:

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Correct answer: DRed line (capillary dilation) then flare (arteriolar dilation via axon reflex) then wheal (increased capillary permeability)

The triple response: (1) red line at the site of injury from local capillary dilation (appears in seconds) / (2) flare (redness spreading beyond the injury site) from arteriolar dilation via an axon reflex / (3) wheal (localised oedema) from increased capillary permeability due to histamine release. This demonstrates local vascular and neural inflammatory responses.

Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist