Plasma Cholinesterase Liver — FRCA Primary MCQ

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EasyPharmacology - General PrinciplesPlasma Cholinesterase LiverFRCA Primary

Plasma cholinesterase (pseudocholinesterase/butyrylcholinesterase) is synthesised in the:

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Correct answer: E — Liver

Plasma cholinesterase is synthesised in the liver. Levels are reduced in: liver disease / pregnancy / malnutrition / burns / renal failure / hypothyroidism / and anticholinesterase drugs. Reduced levels prolong suxamethonium and mivacurium duration. The dibucaine number identifies genetic variants not enzyme quantity.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care