Labetalol Alpha-Beta Blocker — FRCA Primary MCQ
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Correct answer: D — It blocks both alpha-1 and beta adrenergic receptors (alpha:beta ratio approximately 1:7 IV)
Labetalol is a combined alpha-1 and non-selective beta blocker. The alpha:beta blocking ratio is approximately 1:7 when given IV (1:3 orally). This dual action causes vasodilation (alpha-1 blockade) and prevents reflex tachycardia (beta blockade). It is used for controlled hypotension / pre-eclampsia / and hypertensive crises.
Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care