Levosimendan Calcium Sensitiser — FRCA Primary MCQ
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Correct answer: A — Calcium sensitisation of troponin C increasing contractility without increasing intracellular calcium
Levosimendan sensitises cardiac troponin C to calcium increasing contractile force without increasing myocardial oxygen demand (unlike agents that increase intracellular calcium). It also opens ATP-sensitive potassium channels in vascular smooth muscle causing vasodilation. It has some PDE III inhibitory activity. It is used in acute decompensated heart failure.
Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care