Pancuronium Vagolytic Tachycardia — FRCA Primary MCQ

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EasyPharmacology - NeuromuscularPancuronium Vagolytic TachycardiaFRCA Primary

Pancuronium has significant vagolytic activity. This manifests clinically as:

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Correct answer: E — Tachycardia

Pancuronium blocks muscarinic receptors (vagolytic) and also inhibits noradrenaline reuptake at sympathetic nerve terminals. This causes tachycardia and mild hypertension. It has a long duration (60-90 min) and is approximately 80% renally excreted making it unsuitable in renal failure.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care