Gabapentin Alpha-2-Delta — FRCA Primary MCQ
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Correct answer: E — Binding to the alpha-2-delta subunit of voltage-gated calcium channels reducing neurotransmitter release
Despite its name gabapentin does not act at GABA receptors. It binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels reducing calcium influx and subsequent release of excitatory neurotransmitters (glutamate / substance P / noradrenaline). It is used for neuropathic pain and as a perioperative analgesic adjunct.
Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care