Halothane Highest Blood Solubility — FRCA Primary MCQ

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EasyPharmacology - Inhalational AgentsHalothane Highest Blood SolubilityFRCA Primary

Which volatile agent has the highest blood:gas partition coefficient?

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Correct answer: B — Halothane

Blood:gas partition coefficients: halothane 2.3 / isoflurane 1.4 / sevoflurane 0.65 / nitrous oxide 0.47 / desflurane 0.42. Higher blood solubility = slower induction and emergence. Halothane has the highest value and therefore the slowest onset and offset of the commonly used agents.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care