Allosteric Modulation — FRCA Primary MCQ
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Correct answer: D — It binds to a different site on the receptor and modifies the receptor's response to the endogenous ligand
Allosteric modulators bind to a site distinct from the orthosteric (agonist) binding site. Positive allosteric modulators enhance receptor response (e.g. benzodiazepines at GABA-A receptors). Negative allosteric modulators reduce response. They do not activate the receptor directly but modify its response to the primary ligand.
Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care