Hypoxic Drive Peripheral Chemoreceptors — FRCA Primary MCQ
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Correct answer: E — Peripheral chemoreceptors in the carotid and aortic bodies
The ventilatory response to hypoxia is primarily mediated by peripheral chemoreceptors (carotid bodies > aortic bodies). Central chemoreceptors do not respond directly to PaO2. The hypoxic ventilatory response is stimulated when PaO2 falls below approximately 8 kPa (60 mmHg). It is the sole respiratory drive in patients with chronic CO2 retention.
Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist