TCI Three-Compartment Model — FRCA Primary MCQ

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ModeratePharmacology - Intravenous AnaestheticsTCI Three-Compartment ModelFRCA Primary

Regarding total intravenous anaesthesia (TIVA) the target-controlled infusion (TCI) pump uses which pharmacokinetic model for propofol?

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Correct answer: A — Three-compartment model (Marsh or Schnider)

TCI pumps use three-compartment pharmacokinetic models (Marsh or Schnider for propofol / Minto for remifentanil). The pump calculates initial bolus and variable-rate infusion to achieve and maintain a target plasma or effect-site concentration. Marsh uses weight only. Schnider uses age / weight / height / lean body mass.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care