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High CO Slows Induction — FRCA Primary MCQ

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ModeratePharmacology - Inhalational AgentsHigh CO Slows InductionFRCA Primary

Regarding the pharmacokinetics of inhalational agents which factor slows the rate of induction?

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Correct answer: A — High cardiac output

High cardiac output increases pulmonary blood flow removing more agent from the alveoli per unit time. This slows the rise of FA/FI. Conversely shock (low CO) speeds inhalational induction. This is why sick patients may be more sensitive to volatile agents — both pharmacokinetically (faster induction) and pharmacodynamically (greater sensitivity).

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care