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Alpha Cells Glucagon — FRCA Primary MCQ

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HardPhysiology - Endocrine & MetabolicAlpha Cells GlucagonFRCA Primary

Which pancreatic islet cell type secretes glucagon in response to falling plasma glucose?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EAlpha cells that predominantly secrete glucagon

The best answer is “Alpha cells that predominantly secrete glucagon”. Glucagon is secreted by pancreatic alpha cells and raises plasma glucose through hepatic glycogenolysis and gluconeogenesis. Beta cells secrete insulin, delta cells somatostatin and PP cells pancreatic polypeptide. Identifying the cell type is relevant to the integrated counter-regulatory response to hypoglycaemia.

Reference: Royal College of Anaesthetists, Primary FRCA Syllabus 2021: https://www.rcoa.ac.uk/sites/default/files/documents/2026-01/Primary-FRCA-Syllabus.pdf