Labetalol Alpha-Beta Blocker — FRCA Primary MCQ
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Correct answer: A — Alpha-1 blockade combined with non-selective beta-adrenoceptor blockade
The best answer is “Alpha-1 blockade combined with non-selective beta-adrenoceptor blockade”. Labetalol combines alpha-1 blockade, which reduces arteriolar resistance, with non-selective beta blockade, which limits reflex sympathetic cardiac stimulation. Propranolol is a non-selective beta blocker without alpha-1 blockade. The UK SmPC describes this combined mechanism and its relevance to hypertension, including pregnancy and controlled hypotension.
Reference: Labetalol injection, UK Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/10155/smpc