Liver Clotting Factor Synthesis — FRCA Primary MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: B — Synthesis of clotting factors
The liver synthesises most clotting factors (I II V VII VIII IX X XI XII XIII) and fibrinogen. This is a synthetic function distinct from its drug metabolism role (Phase I oxidation/reduction/hydrolysis and Phase II conjugation). Liver failure causes coagulopathy due to reduced clotting factor synthesis measured by prolonged PT/INR.
Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist