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Angiotensin II Effects — FRCA Primary MCQ

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HardPhysiology - RenalAngiotensin II EffectsFRCA Primary

A patient develops acute reduction in effective circulating volume with activation of the renin–angiotensin system. Which intrarenal action of angiotensin II is most helpful initially in preserving glomerular capillary hydrostatic pressure?

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Correct answer: C — Preferential constriction of the efferent arteriole

The best answer is “Preferential constriction of the efferent arteriole”. At physiological activation, angiotensin II preferentially constricts the efferent arteriole, helping maintain glomerular capillary pressure when renal perfusion falls. It also promotes proximal sodium reabsorption, aldosterone, thirst and vasopressin. Predominant afferent constriction would lower glomerular pressure, and the remaining options contradict the volume-conserving angiotensin-II response.

Reference: RCoA, Primary FRCA syllabus: https://www.rcoa.ac.uk/sites/default/files/documents/2026-01/Primary-FRCA-Syllabus.pdf; Renal physiology of glucose handling and therapeutic implications: https://pmc.ncbi.nlm.nih.gov/articles/PMC6993194/