Norpethidine Seizures — FRCA Primary MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: E — Norpethidine accumulates and can cause neurotoxicity including seizures
The best answer is “Norpethidine accumulates and can cause neurotoxicity including seizures”. Pethidine is metabolised to norpethidine, an active metabolite with a longer half-life that can accumulate with repeat dosing, especially in renal impairment. Its accumulation can produce neurotoxicity including seizures. The other mechanisms do not describe pethidine pharmacology.
Reference: Pethidine injection, Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/8941/smpc