Tramadol Dual Action — FRCA Primary MCQ

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ModeratePharmacology - AnalgesicsTramadol Dual ActionFRCA Primary

Tramadol has which dual mechanism of action?

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Correct answer: E — Weak mu agonism and serotonin/noradrenaline reuptake inhibition

Tramadol has weak mu-opioid agonism plus serotonin and noradrenaline reuptake inhibition. Its active metabolite O-desmethyltramadol (M1) has higher mu affinity. Risk of serotonin syndrome with serotonergic drugs (SSRIs / MAOIs).

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care