COX-2 CV Risk Mechanism — FRCA Primary MCQ

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ModeratePharmacology - AnalgesicsCOX-2 CV Risk MechanismFRCA Primary

COX-2 selective inhibitors are associated with increased:

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Correct answer: B — Cardiovascular risk due to inhibition of vascular prostacyclin without affecting platelet thromboxane

COX-2 inhibitors block vascular PGI2 (antithrombotic) production via COX-2 without affecting platelet TXA2 (prothrombotic) production via COX-1. This imbalance increases cardiovascular risk (MI / stroke). Rofecoxib was withdrawn for this reason.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care