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Naloxone All Opioid Receptors — FRCA Primary MCQ

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ModeratePharmacology - AnalgesicsNaloxone All Opioid ReceptorsFRCA Primary

Naloxone is a competitive antagonist at which opioid receptors?

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Correct answer: D — Mu kappa and delta

Naloxone competitively antagonises mu / kappa / delta opioid receptors with highest affinity for mu. Its half-life (30-90 min) is shorter than most agonists requiring repeated dosing or infusion. It reverses all opioid effects including analgesia / respiratory depression / and miosis.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care