Unconjugated Bilirubin Lipid-Soluble — FRCA Primary MCQ
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Correct answer: E — Lipid-soluble and bound to albumin in plasma
Unconjugated (indirect) bilirubin is lipid-soluble and albumin-bound. In hepatocytes it is conjugated with glucuronic acid by UDP-glucuronosyltransferase to become water-soluble conjugated (direct) bilirubin which is excreted in bile and can appear in urine.
Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist