Dexmedetomidine Alpha-2 Sedation — FRCA Primary MCQ

Instant feedback + full explanation. One question, done properly.

EasyPharmacology - AutonomicDexmedetomidine Alpha-2 SedationFRCA Primary

Dexmedetomidine acts at which receptor to produce sedation without significant respiratory depression?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Alpha-2 adrenergic

Dexmedetomidine is a highly selective alpha-2 agonist (1620:1 alpha-2:alpha-1 ratio). It acts at the locus coeruleus for sedation and spinal cord for analgesia. Its sedation resembles natural sleep with maintained respiratory drive.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care