Clonidine Alpha-2 Partial Agonist — FRCA Primary MCQ

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EasyPharmacology - AutonomicClonidine Alpha-2 Partial AgonistFRCA Primary

Clonidine is a partial agonist at which receptor?

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Correct answer: B — Alpha-2

Clonidine is a partial alpha-2 agonist. Central alpha-2 stimulation in the locus coeruleus reduces sympathetic outflow producing sedation / anxiolysis / analgesia / MAC reduction / and reduced salivation.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care