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Insulin GLUT4 — FRCA Primary MCQ

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EasyPhysiology - Endocrine & MetabolicInsulin GLUT4FRCA Primary

Insulin promotes cellular glucose uptake by which mechanism?

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Correct answer: A — GLUT4 transporter translocation to the cell surface

Insulin triggers GLUT4 translocation to the cell surface in skeletal muscle and adipose tissue via tyrosine kinase receptor signalling. It also promotes glycogen synthesis / lipogenesis / protein synthesis while inhibiting gluconeogenesis and glycogenolysis.

Reference: Power Kam 2018 Principles of Physiology for the Anaesthetist