Pancuronium Renal Failure — FRCA Primary MCQ

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ModeratePharmacology - NeuromuscularPancuronium Renal FailureFRCA Primary

In renal failure which neuromuscular blocker has the most prolonged duration?

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Correct answer: E — Pancuronium

Pancuronium is ~80% renally excreted with significantly prolonged duration in renal failure. Atracurium and cisatracurium undergo Hofmann elimination independently of organ function. Mivacurium is metabolised by plasma cholinesterase.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care