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Propofol Vd Steady State Value — FRCA Primary MCQ

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HardPharmacology - Intravenous AnaestheticsPropofol Vd Steady State ValueFRCA Primary

Propofol steady-state volume of distribution is approximately:

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Correct answer: E — 200-300 L

Propofol Vd(ss) is approximately 200-300 L (3-4 L/kg) due to extensive tissue distribution particularly into fat. The initial Vd (central) is ~20 L. The large Vd with high clearance accounts for its pharmacokinetic profile.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care