PRIS Features — FRCA Primary MCQ

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ModeratePharmacology - Intravenous AnaestheticsPRIS FeaturesFRCA Primary

Propofol infusion syndrome features include:

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Correct answer: B — Rhabdomyolysis, metabolic acidosis, cardiac failure, hyperlipidaemia

PRIS is a rare potentially fatal condition with high-dose prolonged propofol infusions (>4 mg/kg/h for >48 hours). Features: metabolic lactic acidosis / rhabdomyolysis / hyperkalaemia / lipaemia / hepatomegaly / cardiac failure / renal failure.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care