Anaphylaxis IgE Mediated — FRCA Primary MCQ
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Correct answer: D — IgE
Type I hypersensitivity is mediated by IgE. Prior sensitisation leads to IgE binding to mast cell FcεRI receptors. Re-exposure causes cross-linking and degranulation releasing histamine / tryptase / leukotrienes / and prostaglandins. Neuromuscular blocking agents are the commonest cause of anaesthetic anaphylaxis.
Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care