Alpha Phase Redistribution — FRCA Primary MCQ

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ModeratePharmacology - General PrinciplesAlpha Phase RedistributionFRCA Primary

In a three-compartment model the alpha phase represents:

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Correct answer: E — Redistribution from vessel-rich organs to muscle

Alpha phase: rapid distribution from central compartment to shallow peripheral compartment (muscle/viscera). Beta phase: slower distribution to deep peripheral compartment (fat). Gamma phase: terminal elimination. Redistribution from brain to muscle accounts for clinical offset of single-dose IV induction agents.

Reference: Peck Hill Williams 2014 Pharmacology for Anaesthesia and Intensive Care